Abstract: A brand new research highlights a big hyperlink between extended use of sure progestogen hormone medication and an elevated threat of growing intracranial meningioma, a kind of mind tumor. Researchers analyzed information from 18,061 ladies who underwent surgical procedure for intracranial meningioma, evaluating their progestogen use to 90,305 controls.

The research discovered that extended use of particular progestogens, together with medrogestone, medroxyprogesterone acetate, and promegestone, is related to an elevated threat of requiring surgical procedure for meningioma. This analysis underscores the pressing want for additional research to grasp this threat absolutely, particularly given the widespread use of those hormones in treating circumstances like endometriosis and as a part of contraceptive strategies.

Key Information:

1. Hyperlink to Mind Tumours Recognized: Extended use of sure progestogens is related to a 2.7 to five.6-fold elevated threat of intracranial meningioma requiring surgical procedure.
2. Huge Use of Progestogens: Medroxyprogesterone acetate, one of many progestogens linked to elevated meningioma threat, is used for contraception by an estimated 74 million ladies worldwide.
3. Want for Additional Analysis: The research requires pressing additional investigation to raised perceive the dangers related to progestogen use, contemplating the potential public well being implications.

Supply: BMJ

Extended use of sure progestogen hormone medication is related to an elevated threat of growing a kind of mind tumour generally known as an intracranial meningioma, finds a research from France revealed by The BMJ in the present day.

The researchers say this research is the primary to evaluate the chance related to progestogens utilized by hundreds of thousands of ladies worldwide, and additional research are urgently wanted to realize a greater understanding of this threat.

Progestogens are much like the pure hormone progesterone, that are broadly used for gynaecological circumstances reminiscent of endometriosis and polycystic ovary syndrome, and in menopausal hormone remedy and contraceptives.

Meningiomas are principally non-cancerous tumours within the layers of tissue (meninges) that cowl the mind and spinal twine. Elements reminiscent of older age, feminine intercourse, and publicity to a few high-dose progestogens (nomegestrol, chlormadinone, and cyproterone acetate) are already identified to extend the chance of meningioma.

However there are numerous different progestogens for which the chance of meningioma related to their use has not been estimated individually.

To deal with this information hole, researchers got down to consider the true life threat of intracranial meningioma requiring surgical procedure in ladies related to use of a number of progestogens with completely different routes of administration.

They used information from the French nationwide well being information system (SNDS) for 18,061 ladies (common age 58) who underwent intracranial meningioma surgical procedure from 2009-18.

Every case was matched to 5 management ladies with out intracranial meningioma (complete 90,305) by yr of delivery and space of residence.

The progestogens examined have been progesterone, hydroxyprogesterone, dydrogesterone, medrogestone, medroxyprogesterone acetate, promegestone, dienogest, and levonorgestrel intrauterine programs.

For every progestogen, use was outlined as a minimum of one prescription within the yr earlier than hospital admission or inside 3-5 years for levonorgestrel intrauterine programs.

Use of a minimum of one of many three high-dose progestogens identified to extend the chance of meningioma within the 3 years earlier than hospital admission was additionally recorded to minimise bias.

After taking account of different doubtlessly influential elements, extended use (a yr or extra) of medrogestone was related to a 4.1-fold elevated threat of intracranial meningioma requiring surgical procedure.

Extended use of medroxyprogesterone acetate injection was related to a 5.6-fold elevated threat, and extended use of promegestone was linked to a 2.7-fold elevated threat.

There gave the impression to be no such threat for lower than one yr of use of those progestogens. 

As anticipated, there was additionally an extra threat of meningioma for ladies uncovered to chlormadinone acetate, nomegestrol acetate, and cyproterone acetate, all of that are identified to extend the chance of meningioma.

Nevertheless, outcomes confirmed no extra threat of meningioma for progesterone, dydrogesterone, or the broadly used hormonal intrauterine programs, whatever the dose of levonorgestrel they contained.

No conclusions could possibly be drawn about dienogest or hydroxyprogesterone because the variety of uncovered people was too small. 

That is an observational research so can’t set up trigger and impact, and the authors acknowledge that the SNDS database lacked info on all of the medical particulars and medical indications for which progestogens are prescribed. Nor have been they capable of account for genetic predisposition and publicity to excessive dose radiation.

Nevertheless, they are saying, on condition that medroxyprogesterone acetate is estimated for use for contraception by 74 million ladies worldwide, the variety of attributable meningiomas could also be doubtlessly excessive.

Additional research utilizing different sources of knowledge are urgently wanted to realize a greater understanding of this threat, they conclude.

About this mind most cancers analysis information

Creator: BMJ Media Relations
Supply: BMJ
Contact: BMJ Media Relations – BMJ
Picture: The picture is credited to Neuroscience Information

Unique Analysis: The findings will seem in The BMJ